izv. prof. dr. sc. Danijel Pravdić

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izv. prof. dr. sc. Danijel Pravdić
Predmet (-i) koje izvodi:
Medicinska fiziologija
ZVANJE:
izv. prof. dr. sc.
Posao:
Prodekan za znanost
DATUM ZADNJEG IZBORA U ZVANJE:
14. prosinca, 2010. godine
TELEFON:
+387 00 000 000

Kratki životopis (opis kretanja u struci)

2005.-danas, Medicinski fakultet Mostar Katedra za fiziologiju – znanstveni novak (2004.-2007.), asistent (2007. – 2010.), docent od 2010.

2004.-2005.: Liječnički pripravnički staž za doktora medicine u Kliničkoj bolnici Mostar;

2007.-2009.: znanstveno-istraživačko usavršavanje iz područja bioenergetika miokarda, Medical College of Wisconsin;

2010.-2013.: Klinička bolnica Mostar, specijalizant interne medicine;

2013.-danas, Klinička Bolnica Mostar, specijalist interne medicine;

2011.-danas, pročelnik Katedre za fiziologiju Medicinski fakultet Mostar

2013.-danas, pročelnik Katedre za bazične medicinske znanosti I, Fakultet zdravstvenih studija Mostar

Iskustvo u nastavi

1999.-2000.: Demonstrator u Zavodu za anatomiju Medicinskog fakulteta Sveučilišta u Mostaru;

2005.-danas, Katedra za fiziologiju, Medicinski fakultet u Mostaru;

2005.-danas, Katedra za fiziologiju, Patofiziologiju i Biologiju stanice s uvodom u genetiku, Fakultet zdravstvenih studija u Mostaru;

2011.-danas, Katedra za fiziologiju Farmaceutski fakultet Sveučilišta u Mostaru;

2007.-2009, Odjel za anesteziologiju, Medical College of Wisconsin (student research assistant).

ZNANSTVENI RADOVI (CC)

  1. PravdicD, SedlicF, MioY, VladicN, BienengraeberM, BosnjakZJ. Anesthetic-induced preconditioning delays opening of mitochondrial permeability transition pore via protein kinase C-ε mediated pathway. Anesthesiology. 2009; 111:267-74.
  2. Sedlic F, Pravdic D, Marinovic J, Ljubkovic M, Stadnicka A, Bosnjak ZJ. Differences in production of reactive oxygen species and mitochondrial uncoupling as events in preconditioning signaling cascade between desflurane and sevoflurane. Anesth Analg. 2009; 109:405-11.
  3. ChengQ, SedlicF, PravdicD, BosnjakZJ, KwokWM. Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel. FEBS Lett. 2011;585:328-34.
  4. Kawano T, Zoga V, Gemes G, McCallum JB, Wu HE, Pravdic D, Liang MY, Kwok WM, Hogan Q, Sarantopoulos C. SuppressedCa2+/CaM/CaMKII-dependentKATPchannelactivityinprimaryafferentneuronsmediateshyperalgesiaafteraxotomy. PNAS. 2009; 106:8725-30.
  5. Ge Z, Pravdic D, Bienengraeber M, Pratt PF Jr, Auchampach JA, Gross GJ, Bosnjak ZJ, Kersten JR, Warltier DC. The cardioprotective effect of isoflurane postconditioning is mediated by eNOS through inhibiting mitochondrial permeability transition in mice. Anesthesiology. 2010;112:73-85.
  6. Pravdic D, Vladic N, Bosnjak ZJ. IntracellularCa2+modulationduringshortexposuretoischemia-mimeticfactorsinisolatedratventricularmyocytes. Collegium Antropologicum Coll Antropol. 2009;33:121-6.
  7. Pravdic D, Mio Y, Sedlic F, Pratt PF, Warltier DC, Bosnjak ZJ, Bienengraeber M. Isoflurane protects cardiomyocytes and mitochondria by immediate and cytosol-independent action at reperfusion. Br J Pharmacol. 2010;160:220-32.
  8. Sedlic F, Sepac A, Pravdic D, Camara AK, Bienengraeber M, Brzezinska AK, Wakatsuki T, Bosnjak ZJ. Mitochondrial depolarization underlies delay in permeability transition by preconditioning with isoflurane: roles of ROS and Ca2+. Am J Physiol Cell Physiol. 2010;299:C506-15.
  9. Sedlic F, Pravdic D, Hirata N, Mio Y, Sepac A, Camara AK, Wakatsuki T, Bosnjak ZJ, Bienengraeber M. Monitoring mitochondrial electron fluxes using NAD(P)H-flavoprotein fluorometry reveals complex action of isoflurane on cardiomyocytes. Biochim Biophys Acta. 2010;1797:1749-58.
  10. Aggarwal NT, Pravdic D, McNally EM, Bosnjak ZJ, Shi NQ, Makielski JC. The mitochondrial bioenergetic phenotype for protection from cardiac ischemia in SUR2 mutant mice. Am J Physiol Heart Circ Physiol. 2010;299:H1884-90.
  11. Alexanian AR, Kwok WM, Pravdic D, Maiman DJ, Fehlings MG. Survival of neurally induced mesenchymal cells may determine degree of motor recovery in injured spinal cord rats. Restor Neurol Neurosci. 2010;28:761-7.
  12. Ge ZD, Ionova IA, Vladic N, Pravdic D, Hirata N, Vásquez-Vivar J, Pratt PF Jr, Warltier DC, Pieper GM, Kersten JR. Cardiac-specific overexpression of GTP cyclohydrolase 1 restores ischaemic preconditioning during hyperglycaemia. Cardiovasc Res. 2011;15;91:340-9.
  13. Hirata N, Shim YH, Pravdic D, Lohr N, Pratt PF, Weihrauch D, Bosnjak ZJ, Judy R. Kerstern, Warltier DC, Bienengraeber M. Isoflurane produces and enhances Reactive Oxygen Species via attenuation of Complex I: Central role of ROS in Anesthetic Preconditioning. Anesthesiology. 2011;115:531-40.
  14. Pravdic D, Hirata N, Barber L, Sedlic F, Bosnjak ZJ, Bienengraeber M. Complex I and ATP synthase mediate membrane depolarization and matrix acidification by isoflurane in mitochondria. Eur J Pharmacol. 2012;690:149-57.
  15. Pravdic D, Vladic N, Cavar I, Bosnjak ZJ. Effect of nitric oxide donors S-nitroso-N-acetyl-DL-penicillamine, spermine NONOate and propylamine propylamine NONOate on intracellular pH in cardiomyocytes. Clin Exp Pharmacol Physiol. 2012;39:772-8.
  16. Kraljevic J, Marinovic J, Pravdic D, Zubin P, Dujic Z, Wisloff U, Ljubkovic M. Aerobic interval training attenuates remodelling and mitochondrial dysfunction in the post-infarction failing rat heart. Cardiovasc Res. Cardiovasc Res. 2013;99:55-64.
  17. Grupa autora (Euro observation research programme). Are hospitalized or ambulatory patients with heart failure treated in accordance with European Society of Cardiology guidelines? Evidence from 12 440 patients of the ESC Heart Failure Long-Term Registry. Eur J Heart Fail. 2013;15:1173-84.
  18. Pravdic D. “Who” can be found in and beyond of an electrocardiographic strip. Pacing Clin Electrophysiol. 2014;37:265-78.

ZNANSTVENI RADOVI (SCI)

  1. Tomić M., Musa D., Pravdić D., Petrović J., Markota I. The correlation of endothelin-1 and nitric oxide with mean arterial pressure depends on therapy with angiotensin-converting enzyme inhibitors in diabetic patients. Kidney & blood pressure research. 2010; 35:430-430.
  2. Yasushi M, Pravdic D, Bosnjak ZJ, Bienengraeber M. Immediate protective mechanisms in postconditioning. Journal of physiological sciences. 2009; 59:319-319.
  3. Mimica M, Pravdic D, Nakas-Icindic E, Karin M, Babic E, Tomic M, Bevanda M. Multiple symmetric lipomatosis: a diagnostic dilemma. Case Rep Med. 2013.
  4. Karin M, Bevanda M, Babić E, Mimica M, Bevanda-Glibo D, Volarić M, Bogut A, Pravdić D. Correlation between biochemical and histopathological parameters in patients with chronic hepatitis C treated with pegylated interferon and ribavirin. PsychiatrDanub. 2014 Dec;26Suppl 2:364-9.

OSTALI RADOVI

  1. Pravdić D, Sedlić F, ŠepacA, Bošnjak ŽJ. Anesthetic-inducedpreconditioning. Medicinskivjesnik. 2008; 40:37-43.

KNJIGE, SKRIPTE, POGLAVLJA U KNJIZI

  1. Čulo F, Pravdić D, Ćavar I, urednici. Fiziologija. Skripta za Višu medicinsku školu. Mostar, 2007.
  2. Aleksić J, Barac-Latas V, Lukinović-Škudar V, Pravdić D, Ćavar I, urednici. Odabrane vježbe iz fiziologije za studente medicine. Priručnik. Mostar, 2007.
  3. Tomić M, Pravdić D. Endokrini poremećaji i gubitak kose. U: Šimić D i Hadžigrahić N, urednice, Bolesti vlasišta i kose, Solvej d.o.o., Mostar, 2010.
  4. Pravdić D, Tomić M. Imunološki mehanizmi u nastanku dermatoloških bolesti. U: Šimić D i Hadžigrahić N, urednice, Hitna stanja u dermatologiji, Avery d.o.o., Mostar, 2011.
  5. Prvadić D. Znanstvene informacije, Etika u farmaciji. U: Tomić M i suradnici, Uvod u farmaciju, Fram-Ziral, Mostar 2012.

KONGRESNA PRIOPĆENJA NA MEĐUNARODNIM SKUPOVIMA

  1. Pravdic D, Sedlic F, Mueller S.J. Bosnjak Z.J. Isoflurane preconditioning delays opening of mitochondrial permeability transition pore via protein kinase C signaling pathway. Experimental biology, San Diego 2008;
  2. Pravdic D, Sedlic F, Stadnicka A, Bienegraeber M, Bosnjak Z.J. Effect of Anesthetic Preconditioning on Mitochondrial Permeability Transition Pore: Role of PKC. Annual Meeting of the American Society of Anesthesiologists, Orlando, 2008;
  3. Pravdic D, Bienengraeber M, Sedlic F, Stadnicka A. Bosnjak Z.J. Intracellular Ca2+ and pH Modulation in Cardiomyocytes during Anesthetic Postconditioning. Annual Meeting of the American Society of Anesthesiologists, Orlando, 2008;
  4. Sedlic F, Pravdic D, Mueller S.J, Stadnicka A, Bosnjak Z.J. Reactive Oxygen Species Play Pivotal Role in Preconditioning by Desflurane and Sevoflurane. Annual Meeting of the American Society of Anesthesiologists, Orlando, 2008;
  5. Bienengraeber M, Mio Y, Pravdic D, Bosnjak Z.J. Direct Effect of Isoflurane on Reactive Oxygen Species Generation. Annual Meeting of the American Society of Anesthesiologists, Orlando, 2008;
  6. Pravdic D, Bosnjak Z.J, Bienengraeber M. Direct effect of isoflurane on mitochondrial pH. Annual Meeting of Biophysical Society, Boston, 2009;
  7. Sedlic F, Tetsuro W, Pravdic D, Bosnjak Z.J. Mitochondrial membrane potential regulates production of reactive oxygen species and opening of mitochondrial permeability transition pore. Experimental biology, New Orleans 2009;
  8. Pravdic D, Mio Y, Sedlic F, Bosnjak Z.J, Bienengraeber M. Mechanism of isoflurane-induced modulation of matrix pH in rat heart mitochondria. American Society of Anesthesiologists, New Orleans, 2009.
  9. Kawano T, Zoga V, Pravdic D, Liang M, Kwok W, Hogan Q, Sarantopoulos C. Loss of regulation of primary aferent neuronal KATP channels by Ca2+/CaM/CaMKII. Association of University Anesthesiologist, Galveston, 2009.
  10. Sedlic F, Pravdic D, Bienengraeber M, Wakatsuki T, Bosnjak Z.J. Preconditioning with isoflurane delays mitochondrial permeability transition pore opening by depolarizing mitochondria. Annual Meeting of American Society of Anesthesiologists, New Orleans, 2009.
  11. Kersten J.R, Zhi-Dong G, Pravdic D, Bienengraeber M, Warltier D.C. Isoflurane postconditioning protects the heart from ischemia/reperfusion injury in an eNOS-dependent manner. Annual Meeting of American Society of Anesthesiologists, New Orleans, 2009.
  12. Mio Y, Pravdic D, Pratt P.F, Warltier D.C, Bosnjak Z.J, Bienengraeber M. Immediate Protective Mechanisms in Postconditioning. International Congress of Physiological Sciences, Kyoto, Japan, 2009.
  13. Vladic N, Pravdic D, Pratt P.F, Ge Z, Warltier D.C, Kersten J.R. Nitric oxide-dependent modulation of superoxide generation in anesthetic postconditioning. Annual Meeting of American Society of Anesthesiologists, New Orleans, 2009.
  14. Pravdic D, Hyrata N, Stowe D.F, Bosnjak Z.J, Bienengraeber M. Complex I and FOF1-atp synthase mediate membrane depolarization and matrix acidification by isoflurane in mitochondria.  Annual Meeting of Biophysical Society, San Francisco, 2010.
  15. Pravdic D, Aggarwal N, Mcnally EM, Bosnjak ZJ, Shi NQ, Makielski JC. Disruption of sulfonylurea receptor-2 protects against ischemia and reperfusion injury via modulation of mitochondrial bioenergetic phenotype. The 5th congress of cardiologists and angiologists of Bosnia and Herzegovina, Sarajevo, 27.-29. svibanj 2010.
  16. Pravdic D, Bienengraeber M, Bošnjak Ž. Mechanism of myocardial protection from ischemia and reperfusion injury by volatile anesthetic isoflurane when applied at reperfusion. The 5th congress of cardiologists and angiologists of Bosnia and Herzegovina, Sarajevo, 27.-29. svibanj 2010.
  17. Tomić M., Musa D., Pravdić D., Petrović J., Markota I. The correlation of endothelin-1 and nitric oxide with mean arterial pressure depends on therapy with angiotensin-converting enzyme inhibitors in diabetic patients. 2nd international symposium on hypertension, 18–21 studeni, 2010, Osijek, Hrvatska.
  18. Pravdic D. ThemitochondrialbioenergeticphenotypeforprotectionfromcardiacischemiainSUR2-mutantmice. ScientificmeetingoftheCroatianphysiologicalsociety, Split, 22.-23. listopad 2010.
  19. KraljevicJ, PravdicD, MarinovicJ, ZubinP, DujicZ, LjubkovicM. Exerciseimprovescardiacmitochondrialfunctioninratswithchronicheartfailure. European Society of Cardiology CongressPariz, 27.-31. kolovoz 2011.
  20. Hirata N, Pravdic D, Bosnjak ZJ, Bienengraeber M. Isoflurane decreases ROS generation via modulation of NADH ubiquinone oxidoreductase activity. Annual Meeting of American Society of Anesthesiologists, New Orleans, 2009. A689.
  21. Bevanda M, Babić E, Pravdić D, Bevanda-Glibo D, Pavlović N. Irritable Bowel Syndrome – Clincal Presentation and Diagnostic Algorithm. 4th Congress of the Gastroenterology Association of Bosnia and Herzegovina, Sarajevo, 25.-28. svibanj 2011.
  22. Bevanda M, Selak S, Pravdić D, Babić E, Bevanda-Glibo D, Zerem E. Hepatocellular Carcinoma: Diagnosis, Staging and Treatment. 4th Congress of the Gastroenterology Association of Bosnia and Herzegovina, Sarajevo, 25.-28. svibanj 2011.
  23. Ćavar I, Kelava T, Pravdić D and Čulo F. Protective effect of anti-thromboxane B2 antibodies in an animal model of acetaminophen-induced liver injury. Scientific meeting of the Croatian physiological society, Osijek, 23.-25. rujan 2011.
  24. Fazlibegović E, Hadžiomerović M, Pravdić D, Palić B. Gender in hospital mortality of the patients with Acute/ Chronic Heart Failure (AHF/CHF) in Clinical Hospital Mostar: the EURObservational Research Programme 2011/2012. 3rd World Heart Failure Congress Istanbul –Turkey. Studeni 29 – Prosinac 02, 2012.
  25. Fazlibegović E, Hadžiomerović M, Palić B, Pravdić D. Factors Related to Short-term Outcome in Heart Failure Patients Hospitalized in Clinical Hospital Mostar – EURObservational Research Program 2011/2012. Heart Failure Congress. Lisabon – Protugal. 25 to 28 May 2013.
  26. Pravdic D, Kraljevic J, Marinovic J, Zubin P, Dujic Z, Wisloff U, Ljubkovic M. Exercise attenuates remodelling and mitochondrial dysfunction in post-infarction failing rat heart. 6th Congress of the Association of Cardiologists and Angiologists of BiH. Tuzla, May 30th – Jun 1st 2013.
  27. Pravdic D, Vladic N, Mimica M, Tomic M. The effect of Ca2+-activated K+ channel inhibitor paxilline on ion fluxes in isolated mitochondria. The 3. Congress of Croatian Physiological Society and 1. Regional Congress of the Physiological Societies, Rijeka, Croatia, from 20-22 September, 2013.

Galić K, Pravdić D, Valentina K. Prognostički značaj laktata, plinske analize i acidobaznog statusa u plućnoj emboliji pesi indexa I-III. 5th congres of Croatian thoracic society, Zagreb, Hrvatska, from 22-25 april, 2015. (ngrada za najbolji poster).

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