{"id":6662,"date":"2026-06-18T13:55:57","date_gmt":"2026-06-18T11:55:57","guid":{"rendered":"https:\/\/mef.sum.ba\/sme\/?page_id=6662"},"modified":"2026-06-22T08:44:13","modified_gmt":"2026-06-22T06:44:13","slug":"laboratorij-za-morfoloske-znanosti","status":"publish","type":"page","link":"https:\/\/mef.sum.ba\/sme\/laboratorij-za-morfoloske-znanosti\/","title":{"rendered":"Laboratorij za morfolo\u0161ke znanosti"},"content":{"rendered":"\t\t
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Laboratorij za morfolo\u0161ke znanosti<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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O nama<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Laboratorij za morfolo\u0161ke znanosti na Medicinskom fakultetu osnovan je 2008 godine.\u00a0 Od tada je uspje\u0161no provedeno vi\u0161e znanstveno-istra\u017eiva\u010dkih projekata. S vremenom ja laboratorij u potpunosti opremljen ure\u0111ajima i pomo\u0107nim instrumentima za izvo\u0111enje tehnika koje se primjenjuju u obradi tkiva.
Za razli\u010dita istra\u017eivanja koja za cilj imaju utvr\u0111ivanje strukturne i funkcionalne povezanosti razli\u010ditih stanica, tkiva i organa, uzorak od interesa je prije svega potrebno fiksirati u formalinu ili drugom fiksativu \u0161to ovisi od vrste tkiva, kao i metodologije koje \u0107e se dalje primjenjivati. Nakon fiksacije slijedi niz koraka kojima tkivo pripremamo za uklapanje u parafinske blokove. Kada su parafinski blokovi spremni, pristupa se izradi histolo\u0161kih rezova na mikrotomu koji se nanose na predmetnice.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Koraci koji slijede ovise o cilju istra\u017eivanja koje se provodi, a mogu biti jedan ili kombinacija dva ili vi\u0161e od navedenih:
-Rutinsko bojanje (H-E)
-Histokemijska bojanja
-Imunohistokemija\/imunofluorescencija
Osim obrade i analize tkiva, u laboratoriju je razvijen i protkol za imunocitokemiju na nativnim razmazima periferne krvi i punktata ko\u0161tane sr\u017ei, kao i na odbojanim (May-Grunwald Giemsa) citolo\u0161kim preparatima.
Tako\u0111er, u tijeku je nabava ure\u0111aja i regencija za fluorescentnu in situ hibridizaciju. Pored navedene metode koristimo protokol za separaciju stanica iz krvi bolesnika s kroni\u010dnom limfati\u010dnom leukemijom. Metode koje se primjenjuju\u00a0 uklju\u010duju kratkotrajno kultiviranje stanica i analizu na proto\u010dnom citometru.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Podru\u010dje istra\u017eivanja<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Procesi nastanka novotvorina i embrionalnog\/fetalnog razvoja \u010dovjeka dijele sli\u010dan izra\u017eajni obrazac genskih puteva, posebice kada je rije\u010d o mati\u010dnim stanicama koje mogu biti izvor nastanka novotvorina. Diferencijacijom mati\u010dnih stanica nastaju razli\u010dite stani\u010dne populacije iz kojih se mogu razviti razli\u010dite vrste karcinoma i limfoma. Isto tako, pod utjecajem mikrookoli\u0161a i genetskih alteracija, razli\u010dite vrste karcinoma i limfoma mogu nastati od iste stanice. Poznavanje razli\u010ditih razvojnih puteva i odstupanje od normalnog obrasca mo\u017ee dovesti do va\u017enih spoznaja o uzroku histolo\u0161ki razli\u010ditih karcinoma i limfoma. Stoga je podru\u010dje interesa na\u0161eg laboratorija prou\u010davanje temeljnih razvojnih procesa poput programirane stani\u010dne smrti (izra\u017eaj pro-apoptotskih \u010dimbenika), pre\u017eivljenja stanica (izra\u017eaj anti-apoptotskih \u010dimbenika), proliferacije (izra\u017eaj mitotskih i postmitotskih \u010dimbenika) i diferencijacije (izra\u017eaj \u010dimbenika rasta i diferencijacije, te specifi\u010dnih receptora) tijekom tumorigeneze (razvoj karcinoma i limfoma) i embriogeneze. U tu svrhu do sada smo radili na tkivima razli\u010ditih organa i struktura (tkiva fetalnih plu\u0107a, sinovijalne membrane, jajnika, zuba, karcinome plu\u0107a, posteljice, te stanice periferne krvi i ko\u0161tane sr\u017ei). Osim ovog temeljnog podru\u010dja interesa imamo nekoliko suradnji s odjelima Sveu\u010dili\u0161ne klini\u010dke bolnice Mostar: Odjel za ginekologiju i porodni\u0161tvo (preeklampsije kod trudnica) i Odjel za ortopediju (razvoj osteoartritisa). Nadamo se da \u0107e rezultati na\u0161ih istra\u017eivanja na\u0107i svoju primjenu u razvoju novih dijagnosti\u010dkih i prognosti\u010dkih biljega koji mogu upu\u0107ivati na rani razvoj bolesti.<\/div>
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Laboratorijske tehnike: klasi\u010dne histolo\u0161ke tehnike, imunohistokemija, imunofluorescencija, imunocitokemija, proto\u010dna citometrija, ELISA (EnzymeLinkedImmunoSorbentAssay), WB.<\/div>
Jedan od najve\u0107ih izazova dana\u0161nje medicine je kako iskoristiti i ujediniti znanja sakupljena na klini\u010dkoj i molekularnoj razini za dobrobit pacijenta.<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"lab,\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Planovi budu\u0107ih istra\u017eivanja<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Kroni\u010dna limfati\u010dna leukemija na primarnim stani\u010dnim kulturama;genski izra\u017eaji indolentnih limfoma Histolo\u0161ka analiza tkiva prosteljice te separacija limfocita T iz postelji\u010dnog tkiva uz primjenu FISH metode i proto\u010dne citometrije; genski izra\u017eaji biljega preeklampsije<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\"laboratory,<\/figure><\/div>
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\u010clanovi tima<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Laboratorij za morfolo\u0161ke znanosti<\/strong><\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Prof. dr. sc. Katarina Vukojevi\u0107<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Prof. dr. sc. Violeta \u0160olji\u0107<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Prof. dr. sc. Mirna Saraga Babi\u0107<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Doc. dr. sc. Sandra Kosti\u0107<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Maja Pivi\u0107, dr. med.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Jelena Skoko, dr.med.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t
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\u201cUloga metaloproteinaza,proliferacije i apoptoze u razvoju fetalnih plu\u0107a \u010dovjeka\u201d, 2013.-2014. Federalno ministarstvo obrazovanja i znanosti
\u201cUloga Alfa-Tubulina, Ki-67 i OCT-4 u ranom razvoju kralje\u017eni\u010dne mo\u017edine \u010dovjeka\u201d, 2012.-2013. Federalno ministarstvo obrazovanja i znanosti
\u201cIzra\u017eaj ZAP-70 proliferativna aktivnost leukemijskih stanica u B-kroni\u010dnoj leukemiji\u201d, 2011.-2012. Federalno ministarstvo obrazovanja i znanosti
\u201cRazvoj perifernog \u017eiv\u010danog sustava u \u010dovjeka\u201d, 2008.-2009. Federalno ministarstvo obrazovanja i znanosti<\/div>
\u00a0<\/div>
Odabrane publikacije proistekle iz laboratorija za morfolo\u0161ke znanosti:<\/strong><\/div>
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  1. \u0160olji\u0107 V, Perak RB, Vukojevi\u0107 K, Saraga-Babi\u0107 M, Bubalo P, Karan D, Todorovi\u0107 J, Batini\u0107 D. ZAP-70 expression and proliferative activity in chronic lymphocytic leukemia. Leuk Lymphoma. 2013 Jun;54(6):1171-6.<\/li>
  2. Kraljevic D, Vukojevic K, Karan D, Rajic B, Todorovic J, Miskovic J, Tomic V, Kordic M, Soljic V. Proliferation, apoptosis and expression of matrix metalloproteinase-9 in human fetal lung. Acta Histochem. 2015 May-Jun;117(4-5):444-50.<\/li>
  3. Miskovic J, Brekalo Z, Vukojevic K, Miskovic HR, Kraljevic D, Todorovic J, Soljic V. Co-expression of TTF-1 and neuroendocrine markers in the human fetal lung and pulmonary neuroendocrine tumors. Acta Histochem. 2015 May-Jun;117(4-5):451-9.<\/li>
  4. Cubela M, Soljic V, Kero D, Vukojevic K, Govorko DK, Saraga-Babic M. Comparison of proliferation, apoptosis and expression of syndecan-1 and \u03b1- SMA in edentulous ridge oral mucosa of successful and early failed submerged dental implants-An immunohistochemical study. Arch Oral Biol. 2016 Mar 2;66:155-164.<\/li>
  5. Ostojic M, Soljic V, Vukojevic K, Dapic T. Immunohistochemical charecterization of early and advanced knee osteoarthritis by NF-kB and\u00a0 iNOS expression. J Orthop Res.2016 Dec 13. doi: 10.1002\/jor.23504. [Epub ahead of print]<\/li>
  6. Orlovic M, Tomic V, Vukojevic K, Hudic I, Mandic V, Azinovic I, Soldo D, Kajic M, Soljic V. Decreased expression of MMP-9 in CD8+cells in placenta with severe preeclampsia. Biotech Histochem 2017 .[prihva\u0107eno za publiciranje]<\/li><\/ol>

    DOKTORSKE DISERTACIJE:<\/strong><\/p>

    1. Josip Mi\u0161kovi\u0107: Zajedni\u010dka izra\u017eenost biljega neuroendokrine diferencijacije i tireoidnog transkripcijskog faktora (TTF-1) u fetalnim plu\u0107ima i plu\u0107nom karcinomu malih stanica. Medicinski fakultet Mostar, 2016.<\/li>
    2. Mladen \u0106ubela: Proliferacija i apoptoza mekog tkiva u podru\u010dju zubnog implantata. Medicinski fakultet Mostar, 2016.<\/li>
    3. Marko Ostoji\u0107: Izra\u017eaj inducibilne NO sintetaze i transkripcijskog \u010dimbenika NF-kB u sinovijskoj membrani bolesnika s osteoartritisom koljena. Medicinski fakultet Mostar, 2015.<\/li>
    4. Tanja Janji\u0107 Zovko: Uloga Ki-67, alfa-tubulina i Oct-4 u ranom razvoju kralje\u017eni\u010dke mo\u017edine \u010dovjeka. Medicinski fakultet Mostar, 2014.<\/li>
    5. Josip Novakovi\u0107: Uloga proliferacije, apopotoze i stani\u010dne diferencijacije u spajanju primarnog i sekundarnog nepca \u010dovjeka. Medicinski fakultet Mostar, 2012.<\/li>
    6. Violeta \u0160olji\u0107: Izra\u017eaj Zap-70 i proliferativna aktivnost leukemijskih stanica u B-kroni\u010dnoj
      limfocitnoj leukemiji. Medicinski fakultet Mostar, 2011.<\/li><\/ol>
      \u00a0<\/div>
      MAGISTARSKI RADOVI<\/strong><\/div>
      1. \u0110ani Godler: Proliferacija i apoptoza u folikulima jajnika \u017eena reproduktivne dobi. Medicinski fakultet Mostar, 2013.<\/li>
      2. Darko Alfirevi\u0107: Klini\u010dko patolo\u0161ka obilje\u017eja ranog relapsa difuznog B-velikostani\u010dnog Ne-Hodgkinovog limfoma s obzirom na podrijetlo stanica iz germinativnog centra folikula. Medicinski fakultet Mostar, 2013.<\/li>
      3. Anka \u0106ori\u0107: Povezanost anksioznosti djece i njihovih roditelja od stomatolo\u0161kog zahvata s indeksom oralnog zdravlja. Medicinski fakultet Mostar, 2011.<\/li>
      4. Josip Novakovi\u0107: Uloga Ki-67, bcl-2 i kaspase-3 \u010dimbenika u razvoju gornje \u010deljusti \u010dovjeka. Medicinski fakultet Mostar, 2009.<\/li>
      5. Katarina Vukojevi\u0107: Uloga Ki-67, kaspaze-3 i bcl-2 u razvoju spinalnih ganglija \u010dovjeka. Medicinski fakultet Mostar, 2008.<\/li><\/ol>
        \u00a0<\/div>
        DIPLOMSKI RADOVI<\/strong><\/div>
        1. Franko Batinovi\u0107: Izra\u017eaj sonic hedgehog u ljudskim fetalnim plu\u0107ima i njegova povezanost s karcinomima plu\u0107a malih i ne-malih stanica. Medicinski fakultet Mostar, 2016.<\/li>
        2. Katarina Vukojevi\u0107: Razlika u osjetu boli izme\u0111u dva \u0161takorska soja Wistar i Sprague-Dawley. Medicinski fakultet Mostar, 2004<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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          Laboratorij za morfolo\u0161ke znanosti O nama Laboratorij za morfolo\u0161ke znanosti na Medicinskom fakultetu osnovan je 2008 godine.\u00a0 Od tada je 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nama\",\"align\":\"left\",\"align_tablet\":\"left\",\"_margin\":{\"unit\":\"px\",\"top\":\"0\",\"right\":\"0\",\"bottom\":\"5\",\"left\":\"0\",\"isLinked\":false},\"_margin_tablet\":{\"unit\":\"px\",\"top\":\"0\",\"right\":\"0\",\"bottom\":\"0\",\"left\":\"0\",\"isLinked\":false},\"display_condition_list\":[{\"display_condition_login_status\":\"subscriber\",\"_id\":\"5060e27\"}]},\"elements\":[],\"widgetType\":\"heading\"},{\"id\":\"4595b33\",\"elType\":\"widget\",\"settings\":{\"editor\":\"

          Laboratorij za morfolo\\u0161ke znanosti na Medicinskom fakultetu osnovan je 2008 godine.\\u00a0 Od tada je uspje\\u0161no provedeno vi\\u0161e znanstveno-istra\\u017eiva\\u010dkih projekata. S vremenom ja laboratorij u potpunosti opremljen ure\\u0111ajima i pomo\\u0107nim instrumentima za izvo\\u0111enje tehnika koje se primjenjuju u obradi tkiva.
          Za razli\\u010dita istra\\u017eivanja koja za cilj imaju utvr\\u0111ivanje strukturne i funkcionalne povezanosti razli\\u010ditih stanica, tkiva i organa, uzorak od interesa je prije svega potrebno fiksirati u formalinu ili drugom fiksativu \\u0161to ovisi od vrste tkiva, kao i metodologije koje \\u0107e se dalje primjenjivati. Nakon fiksacije slijedi niz koraka kojima tkivo pripremamo za uklapanje u parafinske blokove. Kada su parafinski blokovi spremni, pristupa se izradi histolo\\u0161kih rezova na mikrotomu koji se nanose na predmetnice.\\u00a0<\\\/p>\",\"display_condition_list\":[{\"display_condition_login_status\":\"subscriber\",\"_id\":\"0d9cb87\"}]},\"elements\":[],\"widgetType\":\"text-editor\"}],\"isInner\":true},{\"id\":\"4a3c054\",\"elType\":\"column\",\"settings\":{\"_column_size\":50,\"_inline_size\":null,\"_inline_size_tablet\":100,\"space_between_widgets_tablet\":10,\"margin\":{\"unit\":\"px\",\"top\":\"0\",\"right\":\"0\",\"bottom\":\"0\",\"left\":\"40\",\"isLinked\":false},\"margin_tablet\":{\"unit\":\"px\",\"top\":\"50\",\"right\":\"0\",\"bottom\":\"0\",\"left\":\"0\",\"isLinked\":false},\"display_condition_list\":[{\"display_condition_login_status\":\"subscriber\",\"_id\":\"c8dd63c\"}]},\"elements\":[{\"id\":\"244b3a5\",\"elType\":\"widget\",\"settings\":{\"editor\":\"

          Koraci koji slijede ovise o cilju istra\\u017eivanja koje se provodi, a mogu biti jedan ili kombinacija dva ili vi\\u0161e od navedenih:
          -Rutinsko bojanje (H-E)
          -Histokemijska bojanja
          -Imunohistokemija\\\/imunofluorescencija
          Osim obrade i analize tkiva, u laboratoriju je razvijen i protkol za imunocitokemiju na nativnim razmazima periferne krvi i punktata ko\\u0161tane sr\\u017ei, kao i na odbojanim (May-Grunwald Giemsa) citolo\\u0161kim preparatima.
          Tako\\u0111er, u tijeku je nabava ure\\u0111aja i regencija za fluorescentnu in situ hibridizaciju. Pored navedene metode koristimo protokol za separaciju stanica iz krvi bolesnika s kroni\\u010dnom limfati\\u010dnom leukemijom. Metode koje se primjenjuju\\u00a0 uklju\\u010duju kratkotrajno kultiviranje stanica i analizu na proto\\u010dnom citometru.<\\\/p>\",\"display_condition_list\":[{\"display_condition_login_status\":\"subscriber\",\"_id\":\"2ecd433\"}],\"_element_width\":\"initial\",\"_element_custom_width\":{\"unit\":\"%\",\"size\":104.385},\"_flex_size\":\"none\"},\"elements\":[],\"widgetType\":\"text-editor\"}],\"isInner\":true}],\"isInner\":true}],\"isInner\":false}],\"isInner\":false},{\"id\":\"lhhp6me\",\"elType\":\"section\",\"settings\":{\"content_width\":{\"unit\":\"px\",\"size\":1200,\"sizes\":[]},\"structure\":\"20\",\"background_background\":\"classic\",\"background_color\":\"#FFFFFF\",\"background_position\":\"center center\",\"background_attachment\":\"scroll\",\"background_repeat\":\"no-repeat\",\"background_size\":\"cover\",\"background_overlay_color\":\"#F5F5F5\",\"background_overlay_opacity\":{\"unit\":\"px\",\"size\":0.9,\"sizes\":[]},\"padding\":{\"unit\":\"px\",\"top\":\"120\",\"right\":\"0\",\"bottom\":\"120\",\"left\":\"0\",\"isLinked\":false},\"padding_tablet\":{\"unit\":\"px\",\"top\":\"60\",\"right\":\"60\",\"bottom\":\"60\",\"left\":\"60\",\"isLinked\":true},\"padding_mobile\":{\"unit\":\"px\",\"top\":\"60\",\"right\":\"35\",\"bottom\":\"60\",\"left\":\"35\",\"isLinked\":false},\"reverse_order_mobile\":\"reverse-mobile\",\"display_condition_list\":[{\"display_condition_login_status\":\"subscriber\",\"_id\":\"570205a\"}]},\"elements\":[{\"id\":\"f25b8e3\",\"elType\":\"column\",\"settings\":{\"_column_size\":50,\"_inline_size\":65,\"_inline_size_tablet\":60,\"margin\":{\"unit\":\"px\",\"top\":\"0\",\"right\":\"50\",\"bottom\":\"0\",\"left\":\"0\",\"isLinked\":false},\"margin_tablet\":{\"unit\":\"px\",\"top\":\"0\",\"right\":\"20\",\"bottom\":\"0\",\"left\":\"0\",\"isLinked\":false},\"margin_mobile\":{\"unit\":\"px\",\"top\":\"40\",\"right\":\"0\",\"bottom\":\"0\",\"left\":\"0\",\"isLinked\":false},\"padding_mobile\":{\"unit\":\"px\",\"top\":\"0\",\"right\":\"0\",\"bottom\":\"0\",\"left\":\"0\",\"isLinked\":false},\"display_condition_list\":[{\"display_condition_login_status\":\"subscriber\",\"_id\":\"6633a8c\"}]},\"elements\":[{\"id\":\"95f7f62\",\"elType\":\"widget\",\"settings\":{\"title\":\"Podru\\u010dje istra\\u017eivanja\",\"align\":\"left\",\"align_tablet\":\"left\",\"_margin\":{\"unit\":\"px\",\"top\":\"0\",\"right\":\"0\",\"bottom\":\"5\",\"left\":\"0\",\"isLinked\":false},\"_margin_tablet\":{\"unit\":\"px\",\"top\":\"0\",\"right\":\"0\",\"bottom\":\"0\",\"left\":\"0\",\"isLinked\":false},\"display_condition_list\":[{\"display_condition_login_status\":\"subscriber\",\"_id\":\"5060e27\"}]},\"elements\":[],\"widgetType\":\"heading\"},{\"id\":\"73a8420\",\"elType\":\"widget\",\"settings\":{\"editor\":\"

          Procesi nastanka novotvorina i embrionalnog\\\/fetalnog razvoja \\u010dovjeka dijele sli\\u010dan izra\\u017eajni obrazac genskih puteva, posebice kada je rije\\u010d o mati\\u010dnim stanicama koje mogu biti izvor nastanka novotvorina. Diferencijacijom mati\\u010dnih stanica nastaju razli\\u010dite stani\\u010dne populacije iz kojih se mogu razviti razli\\u010dite vrste karcinoma i limfoma. Isto tako, pod utjecajem mikrookoli\\u0161a i genetskih alteracija, razli\\u010dite vrste karcinoma i limfoma mogu nastati od iste stanice. Poznavanje razli\\u010ditih razvojnih puteva i odstupanje od normalnog obrasca mo\\u017ee dovesti do va\\u017enih spoznaja o uzroku histolo\\u0161ki razli\\u010ditih karcinoma i limfoma. Stoga je podru\\u010dje interesa na\\u0161eg laboratorija prou\\u010davanje temeljnih razvojnih procesa poput programirane stani\\u010dne smrti (izra\\u017eaj pro-apoptotskih \\u010dimbenika), pre\\u017eivljenja stanica (izra\\u017eaj anti-apoptotskih \\u010dimbenika), proliferacije (izra\\u017eaj mitotskih i postmitotskih \\u010dimbenika) i diferencijacije (izra\\u017eaj \\u010dimbenika rasta i diferencijacije, te specifi\\u010dnih receptora) tijekom tumorigeneze (razvoj karcinoma i limfoma) i embriogeneze. U tu svrhu do sada smo radili na tkivima razli\\u010ditih organa i struktura (tkiva fetalnih plu\\u0107a, sinovijalne membrane, jajnika, zuba, karcinome plu\\u0107a, posteljice, te stanice periferne krvi i ko\\u0161tane sr\\u017ei). Osim ovog temeljnog podru\\u010dja interesa imamo nekoliko suradnji s odjelima Sveu\\u010dili\\u0161ne klini\\u010dke bolnice Mostar: Odjel za ginekologiju i porodni\\u0161tvo (preeklampsije kod trudnica) i Odjel za ortopediju (razvoj osteoartritisa). Nadamo se da \\u0107e rezultati na\\u0161ih istra\\u017eivanja na\\u0107i svoju primjenu u razvoju novih dijagnosti\\u010dkih i prognosti\\u010dkih biljega koji mogu upu\\u0107ivati na rani razvoj bolesti.<\\\/div>
          \\u00a0<\\\/div>
          Laboratorijske tehnike: klasi\\u010dne histolo\\u0161ke tehnike, imunohistokemija, imunofluorescencija, imunocitokemija, proto\\u010dna citometrija, ELISA (EnzymeLinkedImmunoSorbentAssay), WB.<\\\/div>
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          \\u201cUloga metaloproteinaza,proliferacije i apoptoze u razvoju fetalnih plu\\u0107a \\u010dovjeka\\u201d, 2013.-2014. Federalno ministarstvo obrazovanja i znanosti
          \\u201cUloga Alfa-Tubulina, Ki-67 i OCT-4 u ranom razvoju kralje\\u017eni\\u010dne mo\\u017edine \\u010dovjeka\\u201d, 2012.-2013. Federalno ministarstvo obrazovanja i znanosti
          \\u201cIzra\\u017eaj ZAP-70 proliferativna aktivnost leukemijskih stanica u B-kroni\\u010dnoj leukemiji\\u201d, 2011.-2012. Federalno ministarstvo obrazovanja i znanosti
          \\u201cRazvoj perifernog \\u017eiv\\u010danog sustava u \\u010dovjeka\\u201d, 2008.-2009. Federalno ministarstvo obrazovanja i znanosti<\\\/div>
          \\u00a0<\\\/div>
          Odabrane publikacije proistekle iz laboratorija za morfolo\\u0161ke znanosti:<\\\/strong><\\\/div>
          \\u00a0<\\\/div>
          1. \\u0160olji\\u0107 V, Perak RB, Vukojevi\\u0107 K, Saraga-Babi\\u0107 M, Bubalo P, Karan D, Todorovi\\u0107 J, Batini\\u0107 D. ZAP-70 expression and proliferative activity in chronic lymphocytic leukemia. Leuk Lymphoma. 2013 Jun;54(6):1171-6.<\\\/li>
          2. Kraljevic D, Vukojevic K, Karan D, Rajic B, Todorovic J, Miskovic J, Tomic V, Kordic M, Soljic V. Proliferation, apoptosis and expression of matrix metalloproteinase-9 in human fetal lung. Acta Histochem. 2015 May-Jun;117(4-5):444-50.<\\\/li>
          3. Miskovic J, Brekalo Z, Vukojevic K, Miskovic HR, Kraljevic D, Todorovic J, Soljic V. Co-expression of TTF-1 and neuroendocrine markers in the human fetal lung and pulmonary neuroendocrine tumors. Acta Histochem. 2015 May-Jun;117(4-5):451-9.<\\\/li>
          4. Cubela M, Soljic V, Kero D, Vukojevic K, Govorko DK, Saraga-Babic M. Comparison of proliferation, apoptosis and expression of syndecan-1 and \\u03b1- SMA in edentulous ridge oral mucosa of successful and early failed submerged dental implants-An immunohistochemical study. Arch Oral Biol. 2016 Mar 2;66:155-164.<\\\/li>
          5. Ostojic M, Soljic V, Vukojevic K, Dapic T. Immunohistochemical charecterization of early and advanced knee osteoarthritis by NF-kB and\\u00a0 iNOS expression. J Orthop Res.2016 Dec 13. doi: 10.1002\\\/jor.23504. [Epub ahead of print]<\\\/li>
          6. Orlovic M, Tomic V, Vukojevic K, Hudic I, Mandic V, Azinovic I, Soldo D, Kajic M, Soljic V. Decreased expression of MMP-9 in CD8+cells in placenta with severe preeclampsia. Biotech Histochem 2017 .[prihva\\u0107eno za publiciranje]<\\\/li><\\\/ol>

            DOKTORSKE DISERTACIJE:<\\\/strong><\\\/p>

            1. Josip Mi\\u0161kovi\\u0107: Zajedni\\u010dka izra\\u017eenost biljega neuroendokrine diferencijacije i tireoidnog transkripcijskog faktora (TTF-1) u fetalnim plu\\u0107ima i plu\\u0107nom karcinomu malih stanica. Medicinski fakultet Mostar, 2016.<\\\/li>
            2. Mladen \\u0106ubela: Proliferacija i apoptoza mekog tkiva u podru\\u010dju zubnog implantata. Medicinski fakultet Mostar, 2016.<\\\/li>
            3. Marko Ostoji\\u0107: Izra\\u017eaj inducibilne NO sintetaze i transkripcijskog \\u010dimbenika NF-kB u sinovijskoj membrani bolesnika s osteoartritisom koljena. Medicinski fakultet Mostar, 2015.<\\\/li>
            4. Tanja Janji\\u0107 Zovko: Uloga Ki-67, alfa-tubulina i Oct-4 u ranom razvoju kralje\\u017eni\\u010dke mo\\u017edine \\u010dovjeka. Medicinski fakultet Mostar, 2014.<\\\/li>
            5. Josip Novakovi\\u0107: Uloga proliferacije, apopotoze i stani\\u010dne diferencijacije u spajanju primarnog i sekundarnog nepca \\u010dovjeka. Medicinski fakultet Mostar, 2012.<\\\/li>
            6. Violeta \\u0160olji\\u0107: Izra\\u017eaj Zap-70 i proliferativna aktivnost leukemijskih stanica u B-kroni\\u010dnoj
              limfocitnoj leukemiji. Medicinski fakultet Mostar, 2011.<\\\/li><\\\/ol>
              \\u00a0<\\\/div>
              MAGISTARSKI RADOVI<\\\/strong><\\\/div>
              1. \\u0110ani Godler: Proliferacija i apoptoza u folikulima jajnika \\u017eena reproduktivne dobi. Medicinski fakultet Mostar, 2013.<\\\/li>
              2. Darko Alfirevi\\u0107: Klini\\u010dko patolo\\u0161ka obilje\\u017eja ranog relapsa difuznog B-velikostani\\u010dnog Ne-Hodgkinovog limfoma s obzirom na podrijetlo stanica iz germinativnog centra folikula. Medicinski fakultet Mostar, 2013.<\\\/li>
              3. Anka \\u0106ori\\u0107: Povezanost anksioznosti djece i njihovih roditelja od stomatolo\\u0161kog zahvata s indeksom oralnog zdravlja. Medicinski fakultet Mostar, 2011.<\\\/li>
              4. Josip Novakovi\\u0107: Uloga Ki-67, bcl-2 i kaspase-3 \\u010dimbenika u razvoju gornje \\u010deljusti \\u010dovjeka. Medicinski fakultet Mostar, 2009.<\\\/li>
              5. Katarina Vukojevi\\u0107: Uloga Ki-67, kaspaze-3 i bcl-2 u razvoju spinalnih ganglija \\u010dovjeka. Medicinski fakultet Mostar, 2008.<\\\/li><\\\/ol>
                \\u00a0<\\\/div>
                DIPLOMSKI RADOVI<\\\/strong><\\\/div>
                1. Franko Batinovi\\u0107: Izra\\u017eaj sonic hedgehog u ljudskim fetalnim plu\\u0107ima i njegova povezanost s karcinomima plu\\u0107a malih i ne-malih stanica. Medicinski fakultet Mostar, 2016.<\\\/li>
                2. Katarina Vukojevi\\u0107: Razlika u osjetu boli izme\\u0111u dva \\u0161takorska soja Wistar i Sprague-Dawley. Medicinski fakultet Mostar, 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                  Prof. dr. sc. Mirna Saraga Babi\\u0107<\\\/a><\\\/h6>\\t\\t\\t\\t<\\\/div>\\n\\t\\t\\t\\t<\\\/div>\\n\\t\\t[elementor-element k=\\\"5c05af89ca4780d5bf41d3ffc803714a\\\" data=\\\"eyJpZCI6ImQ2ZjJjNjUiLCJlbFR5cGUiOiJ3aWRnZXQiLCJzZXR0aW5ncyI6eyJlZGl0b3IiOiIiLCJ0ZXh0X2NvbG9yIjoiI0ZGRkZGRiIsImFsaWduX21vYmlsZSI6ImxlZnQiLCJfbWFyZ2luIjp7InVuaXQiOiJweCIsInRvcCI6Ii0xNSIsInJpZ2h0IjoiMCIsImJvdHRvbSI6IjAiLCJsZWZ0IjoiMCIsImlzTGlua2VkIjpmYWxzZX0sImRpc3BsYXlfY29uZGl0aW9uX2xpc3QiOlt7ImRpc3BsYXlfY29uZGl0aW9uX2xvZ2luX3N0YXR1cyI6InN1YnNjcmliZXIiLCJfaWQiOiI1Y2Q4NzdhIn1dfSwiZWxlbWVudHMiOltdLCJ3aWRnZXRUeXBlIjoidGV4dC1lZGl0b3IifQ==\\\"]\\t\\t\\t<\\\/div>\\n\\t\\t<\\\/div>\\n\\t\\t\\t\\t\\t<\\\/div>\\n\\t\\t<\\\/section>\\n\\t\\t\\t\\t
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                  Doc. dr. sc. Sandra Kosti\\u0107<\\\/a><\\\/h6>\\t\\t\\t\\t<\\\/div>\\n\\t\\t\\t\\t<\\\/div>\\n\\t\\t[elementor-element k=\\\"5c05af89ca4780d5bf41d3ffc803714a\\\" data=\\\"eyJpZCI6ImVhNTczYzMiLCJlbFR5cGUiOiJ3aWRnZXQiLCJzZXR0aW5ncyI6eyJlZGl0b3IiOiIiLCJ0ZXh0X2NvbG9yIjoiI0ZGRkZGRiIsImFsaWduX21vYmlsZSI6ImxlZnQiLCJfbWFyZ2luIjp7InVuaXQiOiJweCIsInRvcCI6Ii0xNSIsInJpZ2h0IjoiMCIsImJvdHRvbSI6IjAiLCJsZWZ0IjoiMCIsImlzTGlua2VkIjpmYWxzZX0sImRpc3BsYXlfY29uZGl0aW9uX2xpc3QiOlt7ImRpc3BsYXlfY29uZGl0aW9uX2xvZ2luX3N0YXR1cyI6InN1YnNjcmliZXIiLCJfaWQiOiI1Y2Q4NzdhIn1dLCJjb2x1bW5fZ2FwIjp7InVuaXQiOiJweCIsInNpemUiOjAsInNpemVzIjpbXX19LCJlbGVtZW50cyI6W10sIndpZGdldFR5cGUiOiJ0ZXh0LWVkaXRvciJ9\\\"]\\t\\t\\t<\\\/div>\\n\\t\\t<\\\/div>\\n\\t\\t\\t\\t
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                  Maja Pivi\\u0107, dr. med.<\\\/a><\\\/h6>\\t\\t\\t\\t<\\\/div>\\n\\t\\t\\t\\t<\\\/div>\\n\\t\\t[elementor-element k=\\\"5c05af89ca4780d5bf41d3ffc803714a\\\" data=\\\"eyJpZCI6IjIxODZhOWMiLCJlbFR5cGUiOiJ3aWRnZXQiLCJzZXR0aW5ncyI6eyJlZGl0b3IiOiIiLCJ0ZXh0X2NvbG9yIjoiI0ZGRkZGRiIsImFsaWduX21vYmlsZSI6ImxlZnQiLCJfbWFyZ2luIjp7InVuaXQiOiJweCIsInRvcCI6Ii0xNSIsInJpZ2h0IjoiMCIsImJvdHRvbSI6IjAiLCJsZWZ0IjoiMCIsImlzTGlua2VkIjpmYWxzZX0sImRpc3BsYXlfY29uZGl0aW9uX2xpc3QiOlt7ImRpc3BsYXlfY29uZGl0aW9uX2xvZ2luX3N0YXR1cyI6InN1YnNjcmliZXIiLCJfaWQiOiI1Y2Q4NzdhIn1dfSwiZWxlbWVudHMiOltdLCJ3aWRnZXRUeXBlIjoidGV4dC1lZGl0b3IifQ==\\\"]\\t\\t\\t<\\\/div>\\n\\t\\t<\\\/div>\\n\\t\\t\\t\\t
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