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Projects and Publications


1. “The role of resident memory CD8 + T cells in the brain after congenital cytomegalovirus infection”. Approved by the Federal Ministry of Education and Science in 2016. Project leader: Assoc. Prof. Jurica Arapović.

2. “The study of cytomegalovirus (CMV) infection of the central nervous system in a mouse model”, 2015, scientific research is based on cooperation with the Faculty of Medicine in Rijeka, which is coordinated by professor Stipan Jonjić and professor Jurica Arapović.

3. “The incidence of congenital cytomegalovirus infection in infants in Herzegovina”. Approved by the Federal Ministry of Education and Science in 2010. Project leader: Assoc. prof. Jurica Arapović.

4. “Equipping breeding vivarium for laboratory animals at the University of Mostar” in support of public science and higher education institutions (universities) of importance for the Federation. Approved by the Federal Ministry of Education and Science in 2010. Project leader: Assoc. prof. Jurica Arapović.

5. “System for cryopreservation of tissue and cell samples in liquid nitrogen” in support of public science and higher education institutions (universities) of importance for the Federation. Approved by the Federal Ministry of Education and Science in 2012 at the II. Public Call. Project leader: Assoc. prof. Jurica Arapović.

6.”Molecular mechanisms of cytomegalovirus evasion of immune surveillance”, Ministry of Science and Technology of the Republic of Croatian, Project Leader: Prof. Stipan Jonjić. Period 2004-2008.

7. “Molecular mechanisms of cytomegalovirus evasion of immune surveillance”, Ministry of Science and Technology of the Republic of Croatian, Project Leader: Prof.Stipan Jonjić. The period from 2008 to 2016.

8. “The roles of basic immunological mechanisms in control of herpes virus infection and the development of new vaccines and viral vectors for vaccines,” Project leader: Prof. Stipan Jonjić.



1. Skocibusic S, Martinac M, Arapovic J, Grgic S, Nikolic J, Hasanagic D, M Bevanda, Ravlija J. HBV and HCV serological monitoring among injection drugs users and opiate substitution treatment in Bosnia and Herzegovina. J Infect Dev Ctries. 2016 Sep 30; 10 (9): 968-972. doi: 10.3855 / jidc.7445.

2. Arapović M, Brizić I Popovic B Jurkovic S Jordan S, Krmpotić A Arapović J, Jonjić S. Intrinsic Contribution of perforin to NK Cell Homeostasis during Mouse Cytomegalovirus Infection. Front Immunol. 2016 Apr 6; 7: 133rd doi: 10.3389 / fimmu.2016.00133.

3. Grgic, Skocibusic S, Čeljuska-Tosev E, Nikolic J, J Arapovic, Kuzman I. Different features of influenza A virus infection H1N1pdm09 among adults in the 2009/10 and 2010/11. J Infect Dev Ctries. 2016 Feb 28; 10 (2): 155-62. doi: 10.3855 / jidc.6040.

4. Rajič B Arapović J, K Raguz, Boskovic M, Babic SM, butter S. Eradication of Blastocystis hominis prevents the development of symptomatic Hashimoto’s thyroiditis: a case report. J Infect Dev Ctries. 2015 Oct 30; 9 (7): 788-91. doi: 10.3855 / jidc.4851.

5. Arapović J, M Arapović, Golemac M, L Traven, Tomac J, Rumora D, E Ražić, Krmpotić A Jonjić S. The specific NK cell response in concert with perforin prevents CD8 (+) T cell-mediated immunopathology after mouse cytomegalovirus infection. Med Microbiol Immunol. 2015 Jun; 204 (3): 335-44. doi: 10.1007 / s00430-015-0409-y.

6. Arapović J, Skočibušić S, Jelavic B Ivankovic HB, Juric M, Mamic D Grgic S, J Lesko, Leventić M, Soldo I Ravlija J, Nikolic J. Two cases of human cutaneous anthrax, and Bosnia and Herzegovina, September 2014. Euro Surveill. Feb19 2015; 20 (7): 2-4.

7. Arapovic J, Skocibusic S, S Grgic, Nikolic J. The first evidence of Lyme neuroborreliosis in southern Bosnia and Herzegovina. Case Rep Clin Microbiol. 2014; 2014: 231,969th doi: 10.1155 / 2014 / 231,969th

8. Tršan T Busche A, Abram M, Wensveen FM, ON Lemmermann, Arapovic M, M Babic, Tomic A Golemac M, Brinkmann MM, Jäger W, Oxenius A, B Polic, Krmpotic A Messerli M, Jonjic S. Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1γ. Proc Natl Acad Sci U S A. 2013 Jan 8; 110 (41): 16550-5. doi: 10.1073 / pnas.1310215110.

9. Wagner FM, Brizic I Prager A Tršan T Arapovic M, Lemmermann ON, Podlech J, Reddehase MJ, Lemnitzer F, Bosse JB, Gimpfl M, L Marcinowski, MacDonald M, H Adler, Koszinowski UH, Adler B. The viral chemokine MCC-2 of murine cytomegalovirus infection promotes as part of a gH / gL / MCC-2 complex. PLoS Pathogen. 2013; 9 (7): e1003493. doi: 10.1371 / journal.ppat.1003493.

10. Jordan S, Ruzsics Z, Mitrovic M, Baranek T Arapović J, Krmpotić A, E Vivier, Dalodom M, Jonjić S, L Dölken, Koszinowski UH. Natural killer cells are required for extramedullary hematopoiesis following murine cytomegalovirus infection. Cell Host Microbe. 2013 May 15; 13 (5): 535-45. doi: 10.1016 / j.chom.2013.04.007.

11. Mitrovic M, Arapović J, L Traven, Krmpotić A Jonjić S. Innate immunity regulates adaptive immune response: lessons learned from studying the interplay between NK and CD8 + T cells during MCMV infection. Med Microbiol Immunol. 2012 Oct; 201 (4): 487-95. doi: 10.1007 / s00430-012-0263-0. Review.

12. Mitrovic M, Arapović J, Jordan S, Fodil-Cornu N, S Ebert, Vidal SM, Krmpotić A Reddehase MJ, Jonjić S. The NK cell response to mouse cytomegalovirus infection affects the level and kinetics of the early CD8 (+ ) T-cell response. J Virol. 2012 Feb; 86 (4): 2165-75. doi: 10.1128 / JVI.06042-11.

13. Jordan S, Krause J, Prager A, Mitrovic M, Jonjic S, Koszinowski UH, Adler B. The virus progeny of murine cytomegalovirus bacterial artificial chromosome pSM3fr show reduced growth and salivary glands due to a fixed mutation of MCC-second J Virol. 2011 Oct; 85 (19): 10346-53. doi: 10.1128 / JVI.00545-11.

14. Jovanovic I Radosavljevic G, Mitrovic M, Juranic VL, McKenzie AN Arsenijevic N, S Jonjic, Lukic ML. ST2 deletion enhances innate and acquired immunity to murine mammary carcinoma. Eur J Immunol. 2011 Jul; 41 (7): 1902-12. doi: 10.1002 / eji.201141417.

15. Radosavljevic G, Jovanovic I, I Majstorovic, Mitrovic M, wallets VJ, Arsenijevic N, S Jonjic, Lukic ML. Deletion of galectin-3 and the host attenuates metastasis of murine melanoma tumor by modulating adhesion and NK cell activity. Clin Exp Metastasis. 2011 Jun; 28 (5): 451-62. doi: 10.1007 / s10585-011-9383-y.

16. Slavuljica I Busche A, M Babic, Mitrovic M, Gasparovic I Cekinović D, E Markova Car, Pernjak Pugel E, Ciković A Lisnić VJ, Britt WJ, Koszinowski The Messer M, Krmpotić A Jonjić S. Recombinant mouse cytomegalovirus expressing a ligand for the NKG2D receptor is attenuated and has improved vaccine properties. J Clin Invest. 2010 Dec; 120 (12): 4532-45. doi: 10.1172 / JCI43961.

17. Babic M, M Pyzik, Zafira B, Mitrovic M, Butorac V, Lanier LL, Krmpotić A, Vidal SM, Jonjić S. Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition and natural killer cell-dependent virus control in vivo . J Exp Med.

18. Mohr CA, Arapovic J, Mühlbach H, Panzer M, Weyn A Dölken L, Krmpotic A Voehringer D Ruzsics Z, Koszinowski U, Sacher T. A spread-deficient cytomegalovirus for assessment of first-target cells and vaccination. J Virol. 2010 Aug; 84 (15): 7730-42. doi: 10.1128 / JVI.02696-09.

19. Stanietsky N, Simic, H, J Arapovic, Toporik A, Levy O, Novik A, Levine Z, Beiman M, L Dassa, Achdout H, Stern-Ginossar N, Tsukerman P Jonjic S, Mandelboim O. The interaction of Tigit with PVR and PVRL2 inhibits human NK cell cytotoxicity. Proc Natl Acad Sci U S A. 2009 Oct 20; 106 (42): 17858-63. doi: 10.1073 / pnas.0903474106.

20. Arapovic J, T Lenac, Antulov R Polic B Ruzsics Z, Carayannopoulos LN, Koszinowski UH, Krmpotic A Jonjic S. Differential susceptibility of RAE-1 isoforms to mouse cytomegalovirus. J Virol. 2009 Aug; 83 (16): 8198-207. doi: 10.1128 / JVI.02549-08.

21. Arapović J, Lenac Rovis T Reddy AB, Krmpotić A Jonjić S. Promiscuity of MCMV immunoevasin of NKG2D: M138 / FCR-1 down-modulates RAE-1epsilon in addition to MULT-1 and H60. Mol Immunol. 2009 Nov; 47 (1): 114-22. doi: 10.1016 / j.molimm.2009.02.010 ..

22. Jonjic S, Krmpotic A Arapovic J, Koszinowski UH. Dissection of the antiviral NK cell response by MCMV mutants. Methods Mol Biol. 2008; 415: 127-49. doi: 10.1007 / 978-1-59745-570-1_8.

23. Lenac T Arapović J, L Traven, Krmpotić A Jonjić S. Murine cytomegalovirus regulation of NKG2D ligands. Med Microbiol Immunol. 2008 Jun; 197 (2): 159-66. doi: 10.1007 / s00430-008-0080-7.

24. Lenac T Budt M, Arapovic J, Hasan M, Zimmermann A, H Simic, Krmpotic A Messerli M, Ruzsics Z, Koszinowski UH, Hengel H, Jonjic S. The herpesviral Fc receptor FCR-1 down-regulates the NKG2D ligands MULT-1 and H60. J Exp Med. 2006 Aug 7; 203 (8): 1843-50.